Acute metabolic response to human growth hormone in different types of dwarfism.
نویسندگان
چکیده
منابع مشابه
Acute metabolic response to human growth hormone in different types of dwarfism.
The effectiveness of human growth hormone (H.G.H.) in man is now well established from both the acute metabolic response (Beck et al., 1958 ; Ikkos et al., 1959 ; Medical Research Council, 1959) and the stimulation of growth after long-term therapy (Raben, 1962). In this paper we report the results of studies of the acute metabolic response to injected H.G.H. in different types of dwarfism and,...
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The metabolic response to human growth hormone (HGH) was studied in five obese subjects in the fed state and during prolonged (5-6 wk) starvation. In the fed state (three subjects), HGH induced an elevation in basal serum insulin concentration, a minimal increase in blood and urine ketone levels, and a marked reduction in urinary nitrogen and potassium excretion resulting in positive nitrogen a...
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Small stature or growth retardation is a frequent problem in children, often leading to serious psychological repercussions. In some patients, as for instance in those with achondroplasia, severe hypothyroidism, or classical Turner's syndrome, the underlying disorder can easily be recognized. More often the growth retarded child presents no other symptoms, and the cause of dwarfism remains obsc...
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GH is normally secreted in a pulsatile fashion. When GH is deficient, dwarfism is the result in both rodents and humans. An adenoviral vector containing the rat GH complementary DNA was used to induce constitutive GH expression in hepatocytes of GH-deficient lit/lit mice. Elevated serum GH increased circulating insulin-like growth factor I concentrations, corrected the growth deficiency, and no...
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ژورنال
عنوان ژورنال: BMJ
سال: 1967
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.3.5559.196